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مقاله Abstract


Title: Anti-vascular Endothelial Growth Factor Effect of Topical Timolol for Non-center-involving Diabetic Macular Edema
Author(s): KhMacularalil Ghasemi Falavarjani, Yasaman Hadi, Samira Jafari , Mohammad Mehdi Parvaresh, Mehdi Modarres, Masoud Naseripour,Ahad Sedaghat, Pasha Anvari
Presentation Type: Poster
Subject: Retina and Retinal Cell Biology
Others:
Presenting Author:
Name: Pasha Anvari
Affiliation :(optional) Eye Research Center and Department of Ophthalmology, Rassoul Akram Hospital, Iran University of Medical Sciences
E mail: anvari.p@iums.ac.ir
Phone: 88010558
Mobile: 09122490767
Purpose:

we aim to evaluate the effect of topical timolol in patients with non-center involving diabetic macular edema.

Methods:

In this prospective, interventional case series subjects with non-center-involving diabetic macular edema were treated with topical timolol twice daily for at least three months. Macular thickness at thickest point was measured at baseline, one month and three months.

Results:

Twenty-one eyes of 16 subjects with mean age of 57.09 ±5.98 years (range: 48 to 71) were included. Macular thickness at thickest point was 408.80 ±37.13 (range: 364 to 492) µm, 390.47 ±37.91 µm (range: 307 to 465) and 383.00 ± 30.76 µm (range: 337 to 454)at baseline, one month and three months, respectively. Repeated measure ANOVA revealed that the reduction in macular thickness was significant at one and three months compared with baseline (P=0.005 and P=0.001, respectively).

Conclusion:

We found topical timolol is effective for reducing non-center-involving diabetic macular edema. This effect may be mediated by its anti-vascular endothelial growth factor activity.

Attachment: 46Timolol effica.pptx





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