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مقاله Abstract

Title: Systematic review and meta-analysis investigating autograft versus allograft in cultivated limbal epithelial transplantation in limbal stem cell deficiency
Author(s): Mohammad Amir Mishan, Mozhgan Rezaei Kanavi, Alireza Baradaran-Rafii and Mehdi Yaseri
Presentation Type: Poster
Subject: Cornea & lens
Presenting Author:
Name: Mohammad Amir Mishan
Affiliation :(optional) Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
E mail:
Phone: 09366726488
Mobile: 09366726488

Currently, regenerative medicine has attracted much attention among researchers investigating new methods to treat ocular surface diseases. Based on this new concept, cultivated limbal epithelial transplantation (CLET) has emerged as a promising surgical procedure for treating limbal stem cell deficiency (LSCD). The present review and meta-analysis aimed to compare and determine the efficacy of two different CLET techniques, autologous versus allogeneic, based on a literature review of relevant studies.


A comprehensive search of electronic databases, including PubMed, Google Scholar, and SCOPUS, for related articles was performed in November 2017 to obtain relevant articles to conduct a meta-analysis investigating the success rate of ocular surface regeneration and two-line improvement in visual acuity using autograft and allograft cases.


A total of 33 studies, including 1308 eyes from 1304 patients with LSCD, with a sample size ranging from 3 to 166, and follow-up period of 20 days to 121 months, were reviewed. Of 1308 eyes, 1143 (87.38%) underwent autograft and 165 (12.62%) received allografts from living or deceased donors. Meta-analysis revealed that the success rate and two-line visual acuity improvement using autografts were 1.93 and 1.2 times higher than allografts, respectively (pooled OR 1.93 [95% CI 0.91 to 4.13]; pooled OR 1.2 [95% CI 0.59 to 2.45]); however, the difference was not statistically significant.


Although CLET is a useful therapeutic modality for the treatment of LSCD, the present analysis revealed no significant differences in success rates or visual improvement between autograft and allograft surgical techniques.

Attachment: 51mishan.pptx

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