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مقاله Abstract

Title: Retinal Degeneration Is Being Mediated Through Cistauosis upon Optic Nerve Crush in Mouse Models
Author(s): Sara Poosty1, Zahra Seiedrazizadeh1, Koorosh Shahpasand1, Hossein Baharvand1,2, Leila Satarian1*
Presentation Type: Poster
Subject: Strabismus/ Neuro-Ophthalmology
Presenting Author:
Name: Sara Poosty
Affiliation :(optional) Royan Institute for Stem Cell Biology and Technology
E mail:
Phone: 02122570891
Mobile: 09128199207

Tau abnormal hyperphosphorylation is one of the major pathological hallmarks in retinal disorders including traumatic optic nerve and glaucoma. Despite of extensive consideration it remains uncertain how tau dysfunction contributes to retinopathy. It has been reported that phosphorylated tau at Th231 exists in the two distinct cis and trans conformation which that cis is extremely neurotoxic and is the early driver of tauopathy and neurodegeneration. Thus, we hypothesized that cis p-tau could be the central mediator of neural cell death upon retinopathy


To examine the cis p-tau mediatory role, we initially modeled the mice and then immunostained optic nerve and retinal sections as well as whole retina in various time points (1h, 6h, 24h, 3d, 12d and 21d post crush).


We have found a remarkable increase in cis p-tau levels acutely after crush, which in turn disrupts axonal microtubule network, spreads to other neurons, and leads to apoptosis, a pathogenic process which was termed “cistauosis”. Also, we observed prominent cis p-tau accumulation in whole retina at 21nd days post injury. It is notable that we observed cis-p tau at the earliest 24 hours of crush but not sooner than the point.


These results demonstrate cistauosis as an early pathogenic process of neurodegeneration upon retinopathy and would have profound implications for finding efficient therapeutic strategies.

Attachment: 9ENd poster 9.4.2018.pptx

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  -  شب بهاری چشم پزشکی با رحیم شهریاری
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