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مقاله Abstract


Title: Intravitreal Injection of Zoledronic Acid in a Rat Model of Choroidal Neovascularization
Author(s): Mohammadreza Salarbehzadi 1, Ramin Nourinia 2, Mozhgan Rezaei Kanavi 2, Hamid Ahmadieh 2 Siamak Mashhadi Rafei 1
Presentation Type: Poster
Subject: Physiology/Pharmacology
Others:
Presenting Author:
Name: Mohammadreza Salarbehzadi
Affiliation :(optional) 1- Department of clinical sciences , Faculty of Veterinary Medicine , Science and Research Branch,Tehran,Iran 2- Ophthalmic Research center, Shahid Beheshti University of Medical Sciences,Tehran ,Iran
E mail: mrsbbsrm@yahoo.com
Phone: 02188467618
Mobile: 09122397635
Purpose:

To determine the effects of intra vitreal zoledronic acid (IVZA) on attenuation of laser-induced choroidal neovascularization (CNV) in rats.

Methods:

CNV was induced in 30 pigmented rats via laser burns. Rats were divided into two groups; one group received IVZA (8 μg / 2 μL) and another group received 2 μL normal saline. Neovascularization area was quantified by lectin staining of choroidal-scleral flat mounts by using Image J software.

Results:

Mean CNV area in the IVZA group (30016.02) was significantly less than the controls (43935.49) (P value = 0.059).

Conclusion:

IVZA with dose of 8 μg / 2 μL was effective in attenuation of CNV in rats. To maximize the antiangiogenic effect of IVZA, further investigation using the maximum safe dose of IVZA should be conducted.

Attachment: 99poster 2.pptx





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