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مقاله
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Abstract
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Title:
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Intravitreal Injection of Zoledronic Acid in a Rat Model of Choroidal Neovascularization
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Author(s):
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Mohammadreza Salarbehzadi 1, Ramin Nourinia 2, Mozhgan Rezaei Kanavi 2, Hamid Ahmadieh 2 Siamak Mashhadi Rafei 1
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Presentation Type:
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Poster
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Subject:
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Physiology/Pharmacology
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Others:
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Presenting Author:
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Name:
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Mohammadreza Salarbehzadi
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Affiliation :(optional)
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1- Department of clinical sciences , Faculty of Veterinary Medicine , Science and Research Branch,Tehran,Iran 2- Ophthalmic Research center, Shahid Beheshti University of Medical Sciences,Tehran ,Iran
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E mail:
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mrsbbsrm@yahoo.com
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Phone:
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02188467618
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Mobile:
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09122397635
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Purpose:
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To determine the effects of intra vitreal zoledronic acid (IVZA) on attenuation of laser-induced choroidal neovascularization (CNV) in rats.
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Methods:
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CNV was induced in 30 pigmented rats via laser burns. Rats were divided into two groups; one group received IVZA (8 μg / 2 μL) and another group received 2 μL normal saline. Neovascularization area was quantified by lectin staining of choroidal-scleral flat mounts by using Image J software.
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Results:
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Mean CNV area in the IVZA group (30016.02) was significantly less than the controls (43935.49) (P value = 0.059).
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Conclusion:
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IVZA with dose of 8 μg / 2 μL was effective in attenuation of CNV in rats. To maximize the antiangiogenic effect of IVZA, further investigation using the maximum safe dose of IVZA should be conducted.
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Attachment:
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99poster 2.pptx
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